| March |
| * | 5 | 5:00PM | (A) Bethel - TN | def | (H) Campbellsville - KY | 39-14 | |
| | Make-up of 2/12/21 Game |
| * | | 3:30PM | (A) 4 Lindsey Wilson - KY | def | (H) 19 Georgetown - KY | 35-14 | |
| | No Visiting Fans Allowed |
| February |
| * | 28 | 1:00PM | (A) 14 Saint Xavier - IL | def | (H) Trinity International - IL | 37-28 | |
| | Played at Deaton Field (No fans allowed) |
| * | 27 | 1:00PM | (H) 24 Arizona Christian | def | (A) Oklahoma Panhandle State - OK | 34-7 | |
| * | | 1:00PM | (H) 2 Marian - IN | def | (A) Taylor - IN | 37-14 | |
| * | | 4:00PM | (H) 20 Roosevelt - IL | def | (A) St. Francis - IL | 28-20 | |
| | NO SPECTATORS ALLOWED |
| * | | 1:30PM | (H) Kentucky Christian | def | (A) St. Andrews - NC | 29-24 | |
| * | | 3:00PM | (A) SAGU - TX | def | (H) RV Langston - OK | 31-20 | |
| | | 1:00PM | (A) Madonna - MI | @ | (H) 9 Saint Francis - IN | COVID No Contest | |
| | COVID |
| * | | 12:00PM | (H) 10 Reinhardt - GA | def | (A) Point - GA | 52-0 | |
| | MSC Home Opener |
| * | | 2:00PM | (H) 25 Olivet Nazarene - IL | def | (A) Missouri Baptist - MO | 27-14 | |
| * | | 1:30PM | (A) Faulkner - AL | def | (H) Union - KY | 45-27 | |
| * | | 12:00PM | (A) 13 Concordia - MI | def | (H) 22 Siena Heights - MI | 10-7 | |
| * | | 12:00PM | (A) Indiana Wesleyan | @ | (H) Lawrence Tech - MI | Cncl | |
| * | | 3:00PM | (A) Ottawa - KS | @ | (H) Texas Wesleyan | COVID No Contest | |
| * | | 3:00PM | (H) Wayland Baptist - TX | def | (A) Lyon - AR | 10-0 | |
| * | 26 | 3:30PM | (H) 4 Lindsey Wilson - KY | def | (A) 17 Cumberlands - KY | 45-10 | |
| * | | 5:00PM | (A) Bethel - TN | def | (H) Thomas More - KY | 49-7 | |
| | NAIA Game of the Week |
| * | | | (A) Campbellsville - KY | def | (H) Pikeville - KY | 14-13 | |
| * | | 7:00PM | (A) 19 Georgetown - KY | def | (H) Cumberland - TN | 19-7 | |
| | No Visiting Fans Allowed |
